Brain connectivity study helps explain the neural link between depression and poor sleep quality

first_imgLinkedIn Share on Facebook Email Share Share on Twittercenter_img Pinterest New research has identified functional connectivities in the brain that mediate the association between depressive symptoms and poor sleep quality. The findings were published in JAMA Psychiatry.“Nowadays depression and sleep problem are two of the most prevalent mental problems. To make matters worse, depression and sleep problems often go hand-in-hand, which has been observed more than a hundred years,” said study author Jianfeng Feng of Fudan University.About 75% of depressed patients report significant levels of sleep disturbance and people with insomnia also have a higher risk of developing depression. “However, until now, there was not an efficient way for the treatment of these two problems due to the poor understanding of their underlying mechanism,” Feng explained. “Our research group has worked on depression for more than ten years and produced many significant results. For example, the findings of our previous work published in Brain have shown promise for new treatments.”“In this work, we tried to figure out what are the brain systems associated with both depression and sleep quality. The answers to this question may lead to better treatments for both depression and sleep, especially for improving the sleep quality of depressive patients.”The researchers examined data from 1,017 participants who were included in the March 2017 public data release from the Human Connectome Project. They found that both poor sleep quality and depressive symptoms were associated with neural connectivities involving the lateral orbitofrontal cortex, the dorsolateral prefrontal cortex, the cingulate cortex, and the precuneus.“Our analysis shows that the functional connections between the areas of the brain associated with short-term memory, the self, and negative emotions are increased in both poor sleep and depressive participants. So people with poor sleep or depression may focus too much on the negative things and dwell on bad thoughts, which leads to a poor quality of sleep,” Feng told PsyPost.The study — like all research — has limitations.“We only identified the neural connectivity that underlies the association between depression and sleep. There are many interesting and important questions still need to be addressed,” Feng explained. “For example, the causal relation between sleep and depression is an important topic that deserves much further investigation by using experimental manipulation or treatment administration.”“Another problem is the treatment of sleep problems and depression,” Feng added. “Future research could examine whether we could improve the symptom of insomnia and depression based on our findings, such as using transcranial magnetic stimulation or transcranial direct current stimulation to stimulate the brain areas identified in this work.”The study, “Functional Connectivities in the Brain That Mediate the Association Between Depressive Problems and Sleep Quality“, was authored by Wei Cheng, Edmund T. Rolls, Hongtao Ruan, and Jianfeng Feng.last_img read more

WHO expert: Ebola outbreak to continue at least 6 more months

first_imgIn an interview with CIDRAP News, Peter Salama, MD, the World Health Organization’s (WHO’s) deputy director-general for emergency preparedness and response, said the current Ebola outbreak in the Democratic Republic of the Congo (DRC) is likely to continue for at least another 6 months, as DRC officials today confirmed 5 new cases.”This is the most complicated setting we’ve ever experienced in order to stop an Ebola outbreak,” said Salama. “At a minimum, it will take six further months to stop.”Salama made the sobering prediction alongside some promising developments, including a decrease of cases in Beni, the most active outbreak hot spot, which hasn’t seen any new cases in nearly 2 weeks.”If we can control the outbreak in Beni, we can do it anywhere,” Salama said. Now, the focus is on Butembo and Katwa, areas with nearly 1 million people. Other hot spots include Komanda and Oicha, but Salama said case loads are lighter there.”I feel we will be able to get on top of those with access, which will leave Butembo and Katwa as the main priority,” said Salama.The outbreak, which began in August in North Kivu and Ituri provinces, has been marred by community resistance, population movement, violence against heath workers, and political instability. These factors have limited the response efforts at times and have allowed the disease to continue to take hold of communities.”Though this is the 10th outbreak in the DRC, this is a community and region that has never seen Ebola. There was no baseline knowledge among healthcare workers of in the community about the disease,” said Salama.100 workers recently addedThe WHO now has 450 personnel working in DRC on the outbreak, with 100 of the workers added just in the last month, Salama said.”This is a massive deployment, but people with the ability and willingness to deploy aren’t exactly growing on trees,” he said.The instability and danger is one factor limiting more healthcare workers from the outbreak zone, while another is language, as fluency in both French and Swahili is most useful.While human resources have stretched during the outbreak, Salama said doses of Merck’s unlicensed VSV-EBOV vaccine and in-field Ebola testing kits are in good supply.”Merck has 300,000 doses in the global supply, and we’ve used about 60,000 so far, so we have some buffer,” he said. The goal is to have two licensed vaccine products in the global stockpile by 2020, because that would assist with vaccine production ramp-up.”Were the outbreak to become a multi-country outbreak, then we would quickly face critical vaccine shortages,” said Salama.Why the high rates in children?Salama also shared a working hypothesis he and WHO team members developed to explain the high proportion of cases in young children, those under 5 and under 1 year, during this outbreak.”There are an enormous number of informal health facilities in Beni, Butembo and Katwa. In Beni [there are] around 400 that are not regulated and had never been mapped, so no one could have told you how many there were, where they were, who staffed them, or what kind of services they supplied,” Salama said.These facilities are known locally as “tradi-moderns,” or traditional-modern health centers. They are private businesses, and employees do not need any medical licenses or certificates.”We believe they had a tremendous impact on transmission,” Salama said. “We saw in November a trend of children being infected, and we were able to detect cases associated with a relatively small number of facilities.”The Ebola infections occurred at the same time of a malaria outbreak.”Unbeknownst to anyone, children were sharing rooms with Ebola patients who were not suspected or diagnosed, and there were no medical records taken,” Salama said.Case totals rise to 668, with 410 deathsAccording to today’s daily update from the DRC’s ministry of health, the outbreak has grown to 668 cases and 410 deaths, with 136 cases still under investigation, up from 123 yesterday. Of the 5 newly confirmed cases, 3 are in Kayina, with 1 each in Katwa and Mangurujipa.Kayina is the 18th health district involved in this outbreak, and the site of two community deaths. The DRC said the cases in Kayina are family members.As of today, 61,201 people have been vaccinated , including 19,990 in Beni, 12,815 in Katwa, 6,796 in Butembo, 5,741 in Mabalako, 2,433 in Kalunguta, and 2,080 in Komanda.See also Jan 17 DRC updatelast_img read more

On The Job In Los Alamos: At Subway On Central

first_imgOn the job in Los Alamos Thursday afternoon is Soran Singh at Subway. Subway offers a wide variety of foods every day and recently added a new cookie to the menu. Subway is at 1370 Central Ave. and open 6:30 a.m. to 9 p.m. Monday through Friday and 8:30 a.m. to 9 p.m. Saturday and Sunday. For more information, call 505.661.9769. #worklosalamos #where discoveriesaremade. Photo by Jenn Bartram/ladailypost.comlast_img

China suffers significant decrease in rare gas imports

first_imgSubscribe Get instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270.last_img

Back to earth

first_imgTo continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters Get your free guest access  SIGN UP TODAY Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our community Subscribe now for unlimited accesslast_img read more

Oviedo groomer opens doors overnight to care for dog found on side of road

first_img SHARE Do you see a typo or an error? Let us know. Oviedo groomer opens doors overnight to care for dog found on side of road Published: October 13, 2017 10:43 PM EDT Updated: October 13, 2017 10:48 PM EDT OVIEDO, Fla. (WKMG) A Seminole County grooming business opened its doors overnight Wednesday to offer a matted dog found on the side of the road some relief.Employees with BGE Grooming in Oviedo said a good Samaritan saved the dog Wednesday night from being hit by a car on Conroy Road in Orange County.Groomers posted before and after pictures of the dog Thursday morning, after they gave him an “emergency grooming” when the people who found the dog brought it by around midnight.Employees said the dog’s mats were in such bad condition that he couldn’t walk or use the bathroom.“They were soaking wet, infested with fleas, full of yeast infection and attached like a mummified cast,” employees wrote on BGE’s Facebook page. “The smell was horrendous.”They said knew it was an emergency as soon as they saw him.The grooming session took two hours and the dog was unrecognizable following his haircut.Salon owner Kari Falla said she didn’t think twice about opening the salon and taking care of him.“We always groom rescue dogs and shelter does for free, so as soon as I found out, it was a no brainer,” Falla said. “We believe in paying it forward. Sharing a little bit of kindness goes a lot way. And in this case, it saved a life.”Pictures and videos show the dog looking much happier and healthier because of his new style.The good deed received a lot of attention on Facebook. Employees have been posting updates about the dog on the BGE Grooming page.Groomers said the dog, which is believed to be a Goldendoodle mix, stayed at the business overnight Thursday and was neutered Friday. He is now in the care of a veterinarian and officials are searching for his original owner.last_img read more

Law firms face ethnicity pay gap headache

first_imgSamantha MangwanaCM Murray‘It is only by requiring similar transparency on the ethnicity pay gap that organisations will start to understand this problem in order to tackle it,’ she said. ‘While the ‘glass ceiling’ blocking female leadership in the work place is now recognised, this is part of a double whammy faced by many black and ethnic minority people, for whom ‘sticky floors’ prevent them from progressing in the first place.’Meanwhile, City firms Norton Rose Fulbright and Baker McKenzie are among signatories a charter committing themselves to ensuring employees from a minority ethnic background succeed. The Race at Work Charter commits businesses to principles and actions to help the recruitment and progression of minority ethnic employees.Sarah Gregory, diversity and inclusion partner at Baker McKenzie, said: ‘Huge progress has been made to improve the experience of ethnic minority colleagues in the workplace, but more still needs to be done. This is why, we are very excited today to be signing the Race at Work Charter and together with the government and other businesses look at improving ethnic minority representation at all levels of seniority.’ Law firms could face another dilemma about whether or not partners should be treated as employees as the prospect of ethnicity pay gap reporting looms.The government has begun seeking organisations’ views on reporting the pay gap for people from different ethnic backgrounds. The consultation, open until January, promises to set out in detail what information employers should publish. A Downing Street spokesperson did not respond to a request for comment on the critea for reporting and whether law firms will be required to include partners in the data.During this year’s gender pay gap reporting law firms came under fire for omitting partners on the grounds that they are ‘not employees’. Several firms subsequently recalculated their reports to include partners, after which the average gender pay gap signigicantly increased.Samantha Mangwana, partner at CM Murray, said the gender pay gap reporting showed the scale of the problem and provided a ‘catalyst for change’.last_img read more

DB tests larger version of CRRC hybrid shunting locomotive

first_imgGERMANY: Trials are underway with a larger version of the AZLok shunting and engineering train locomotives which Deutsche Bahn has ordered from China’s CRRC Zhuzhou.DB ordered four 750 kW four-axle diesel-battery hybrid locomotives from CRRC Zhuzhou in June 2018 at a cost of €10m, with options for up to 16 more.The first of two small-profile locomotives intended for hauling engineering trains on S-Bahn networks was delivered to Germany in late August 2018.The third locomotive, which arrived in Hamburg this March, is 2·3 m longer at 16·7 m, has a 16 tonne rather than 14 tonne axleload and a higher maximum speed of 100 km/h rather than 80 km/h.last_img