A missed opportunity

first_imgWhat was expected to be a historical event at the D’Urban Park arena where the Government and Opposition would have sat side by side to celebrate Guyana’s 50th independence anniversary turned out to be a huge blunder and embarrassment for the Administration.The People’s Progressive Party/Civic (PPP/C) was no doubt insulted and disrespected when they, just like other Guyanese, committed to patriotism, put politics aside and joined the Government in celebrating the country’s significant milestone.Rather than being welcomed for this act of partnership, the country’s Opposition were given a cold shoulder and left standing, with no proper accommodation for them at the country’s premier event. This act defies all calls of unity and social cohesion. As a matter of fact, the ill-mannered act comes 24 hours after Opposition Leader Bharrat Jagdeo in his address to the National Assembly said Guyanese need to work together in order for the country to truly prosper.In his speech, the Opposition Leader also pointed out that the Party wants the country’s people to live together in harmony and not be divided by history and by current circumstances.More importantly, the Opposition Leader said that “regardless of the robust debates that we have; regardless of the numerous encounters we have wherever we go in the streets or on television or in the debates, we are all children of this soil. We all share its history.”The sincerity of this speech was demonstrated when Jagdeo and his MPs turned up at D’Uban Park on Wednesday night. However, this act by the Government now raises the question of their genuineness when calls are made for unity and social cohesion. The President on numerous occasions outlined that the country’s future depends on deeper social cohesion and political inclusiveness.Only recently in his address to the National Assembly, the Head of State said, “Social cohesion is about fostering greater integration in our nation. Integration can increase a sense of belonging. It can give recognition to all groups and to allow them to freely practice their culture… Our nation’s future stability depends, also, on wider political inclusiveness…”As a matter of fact, no other than the Head of State himself, in his independence message to the nation said that the country has made headway in uniting its people. To give lip service to such an important issue in a delicate nation, by all means should be rejected by Guyanese.The political Opposition’s acceptance of the invitation to participate in the events at D’Urban Park demonstrates maturity and seriousness towards inclusiveness as Guyana moves forward. However, to leave the Opposition standing at such an event sends a message of pure disregard and disparage.The President should launch an immediate investigation into such humiliation especially given the fact that the Opposition Leader spoke to the Attorney General and Minister responsible for culture about the concerns of the PPP/C MPs being seated.Both Ministers should be held accountable for the utter disrespect since although requesting an intervention, the concerns aired by the Opposition Leader fell on deaf ears. It can be recalled that at past independence celebrations that were held at the National Park, the VIP sections were reserved for all MPs, diplomats and special invitees.Such uncouth behaviour was not extended by the previous Administration and the President should not condone it either. As a matter of fact, a public apology should be extended to the People’s Progressive Party and the President should reprimand those responsible for such callous, irresponsible and destructive behaviour extended to the political Opposition.last_img read more

911 emergency a worrying situation

first_imgOn Saturday last, the local media reported that several calls by media consultant Alex Graham to the 911 emergency line went unanswered as he and his family sought help from the Police after be robbed.This is not the first time that the media has reported that the highly touted 911 system is not working effectively as is being publicised by both the Public Security Ministry and the Guyana Police Force. There were previous instances where media reports exposed a call to 911, while an armed robbery might have been in progress, resulted in the caller being given a number for the Police station with jurisdiction and told to call there. While in that instance the positive is that the 911 call was actually answered, from all understanding, operators are expected to take pertinent information and relay same through its internal network.Many, over the years, have lamented the poor 911 service. In desperate situations when crimes are being committed, and which could mean the difference between life and death, the citizenry would naturally expect not just professionalism, but a swift and effective response by law enforcement. There can be no alternative to this.Sometime back an upgrade to the 911 system was reported as well as the cost for same. With such overdue and desired improvement, the reason for a 911 operator providing a number for a station and asking the person seeking assistance to make another call, as precious time ticks away, is beyond comprehension. That station number could be engaged or go unanswered, as experienced by some, further delaying a much needed response.In addition, some repeated excuses as per the media and victims, are, “you need to call another station as this one does not have jurisdiction” and “only two ranks are at the station and as such are unable to assist”. Unfortunately this has been the harsh reality for some. It renews the nagging concern over the many ranks seen on the roadways at any given time dealing with traffic related issues but often not enough in the nights to respond to armed robberies.Motorists have alleged of being unduly harassed by Policemen during the day and it is not unusual to hear of that disparity in presence alluded to. This does not take away from the need to curb errant road users; however taxpayers would expect nothing short of the desired response when it comes to attack from bandits.In many past incidents of crime, often the sloth or lack of a response by the Police is noted. Again, this does not take away from the fact that there were times when the Police responded promptly and confronted the armed perpetrators. However, none can deny the distressing reports of residents bemoaning the lack of a timely response. Sentiments would be further riled in the unfortunate circumstances when a life is lost at the hands of bandits.Experiencing an attack by armed bandits is a most traumatising experience which can linger with time. It haunts and is relived over and over in the minds of the victims. Indirectly, relatives are also affected having to grapple with the horror their loved ones were forced to endure. Tardiness and a perceived lack of concern by the Police would therefore only serve to exacerbate sentiments.While such trauma would be referred to in the reports, there is uncertainty over mechanisms, if any, that is implemented for mitigation. This is clearly an area for which capacity building is urgently needed and which could help foster improved relationship between the related authorities and residents.Obviously the Police have challenges and one is the inadequate number of ranks. That reality unfortunately does not bring respite to residents who find it difficult to accept excuses for slow or a lack of response. These scenarios have unfortunately led to an erosion of confidence in the Police by many citizens and understandably so. There is further erosion when Policemen are fingered and charged for breaking the law including, committing or assisting acts of robberies.With crime being everybody’s business, the Police leadership and the ranks will have to be supported and they must continue to find innovative ways of meaningfully engaging residents and to be effective to build confidence in all aspects of the system, including 911. Our safety demands nothing less.last_img read more

3 Hawthorne men nabbed in robbery of Torrance Starbucks, customers

first_img AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREWhicker: Clemson demonstrates that it’s tough to knock out the champAuthorities do not yet know how much money was taken, he added. The robbers left the coffee shop in a white sport utility vehicle, and were soon spotted by patrolling Torrance police officers near Artesia Boulevards and Western Avenue, Crespin said. The suspects fled, leading officers on a pursuit with speeds up to 100 mph over the eastbound Artesia (91) Freeway, northbound San Gabriel River (605) Freeway, westbound Glenn Anderson (105) Freeway and onto the northbound Harbor (110) Freeway, Crespin said. After officers bumped the vehicle as it exited on Third Street in downtown Los Angeles, the car spun and slammed into a guard rail, Crespin said. The three suspects fled the vehicle, and Dasher jumped off the exit’s bridge, injuring his ankle on the 15-foot drop. Officers immediately apprehended the suspects, Crespin said. The three men are charged with multiple robbery counts, as well as evading arrest, Crespin said. An arraignment date has not been set, he added. Sawyer is held on $126,000 bail, and Roberson is held without bail as he is violation of parole, Crespin said. andrea.woodhouse@dailybreeze.com160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! Police arrested three Hawthorne men late Wednesday after they allegedly robbed more than a dozen customers at a Torrance Starbucks and led officers on a 25-minute freeway pursuit, authorities said. Christopher Sawyer, 21, and Sidney Roberson, 26, were booked and in police custody Thursday, said Torrance police Officer Dave Crespin. A third suspect, Kenyatta Dasher, was at Harbor UCLA Medical Center for treatment of an ankle injury sustained during the police pursuit, Crespin said. Armed with handguns, the suspects allegedly entered the coffee shop near the corner of Crenshaw and Sepulveda boulevards around 10:10 p.m. Wednesday and robbed 13 customers and employees, Crespin said. last_img read more

Unai Emery drops massive hints star midfielder will start against Spurs

first_imgUnai Emery dropped five potentially crucial hints Mesut Ozil will start the north London derby against fierce rivals Tottenham Hotspur on Saturday afternoon.The clash, which will be held at Wembley and not Spurs’ new ground, is live on talkSPORT from 12.30pm. tense Mesut Ozil was unstoppable on Wednesday against Bournemouth Ozil was at his mercurial, magical best on Wednesday against Bournemouth – scoring a signature ‘bounced’ shot at the Emirates in the 5-1 drubbing.The German also grabbed a routine assist and looks back to his best, a far cry from the player who was left out of the side to face West Ham in January for ‘tactical reasons’.But when facing the media on Friday, Emery sounded like he was ready to trust the 30-year-old with a starting berth.However, the Spaniard would not go as far as to say he would actually be naming Ozil in his starting XI. latest gameday cracker Berahino hits back at b******t Johnson criticism – ‘I was in a dark place at Stoke’ Liverpool news live: Klopp reveals when Minamino will play and issues injury update REPLY Sky Sports presenter apologises for remarks made during Neville’s racism discussion MOST POPULAR FOOTBALL STORIES Green reveals how he confronted Sarri after Chelsea’s 6-0 defeat at Man City huge blow whoops The German bounced his shot into the ground over the despairing Artur Boruc center_img The relationship between Ozil and Emery has been tense, to say the least The average first-team salaries at every Premier League club in 2019 revealed 3) “Want to watch every player”When quizzed on whether he now trusts Ozil to play in big games, he hinted the former Real Madrid star has now regained his trust.He said: “I want to watch every player play in all the matches against the big teams, against all the teams.”4) “Ozil has the confidence”Ozil has only scored five times in 21 matches for the Gunners this season, but Emery believes he now has confidence on his side. SORRY Boxing Day fixtures: All nine Premier League games live on talkSPORT 3 Did Mahrez just accidentally reveal Fernandinho is leaving Man City this summer? Oxlade-Chamberlain suffers another setback as Klopp confirms serious injury 1) “Players are all well”The midfielder has missed a number of matches and training sessions this season due to either illness or injury.The former Paris Saint-Germain boss confirmed Ozil will available for the derby when he said: “No more injuries. Our other players are all well.”2) “Play with the best players”Emery stated his intentions to field his strongest team – which presumably would include Ozil – when he takes the Gunners to Wembley.He said: “We are going to play with the best players on the pitch, our best players, and the big test is whether every player can be ready to play to show how we are now.” 3 3 The Spaniard added: “Each player has the skills and Ozil has the confidence to shoot like that.”5) “Players with these skills”Emery was left stunned by Ozil’s technique when he scored the opener against the Cherries on Monday.He claimed: “I think it’s also amazing that football can have players with these skills and able to do different things on the pitch.”last_img read more

Bale’s uncertain future, Man United eye Wan-Bissaka, Welbeck’s shock Arsenal deal

first_img 3 LATEST FOOTBALL GOSSIP ON talkSPORT.COM Arsenal transfer news LIVE: Ndidi bid, targets named, Ozil is ‘skiving little git’ LATEST Kevin De Bruyne ‘loves Man City and wants to keep winning’, reveals father Man United joined by three other clubs in race for Erling Haaland Arsenal are considering giving injured striker Danny Welbeck a new contract. The 28-year-old on course to return to training before the end of the season. (The Independent)Chelsea boss Maurizio Sarri has admitted he has become accustomed to fans calling for him to be sacked. (Daily Express)United are refusing to agree to Ander Herrera’s £200,000-a-week wage demands, which means they may lose the 29-year-old in the summer when his contract expires. Spaniard Herrera has reportedly been approached by Paris Saint-Germain. (Daily Mirror)Barcelona have made contact with Juan Mata’s father and agent about a possible move for the Man United midfielder, whose deal is also up in the summer. (The Sun) Could Gareth Bale be on his way back to Tottenham this summer? The biggest market value losers in 2019, including Bale and ex-Liverpool star Gareth Bale’s future at Real Madrid will be decided at the end of the season, manager Zinedine Zidane has revealed. The 29-year-old Welsh star has been linked with Manchester United and Tottenham – FULL STORY Manchester United could make a £35million bid for Crystal Palace full-back Aaron Wan-Bissaka in the summer. (Daily Mail)Tottenham’s new stadium will help attract more top players to the club, believes former midfielder Juan Sebastian Veron, who played for Inter Milan’s legends team against Spurs at the weekend. (Daily Mirror) 3 RANKED talkSPORT.com rounds up all the latest gossip from Monday’s newspapers and online after another eventful weekend of Premier League action… REVEALED Top nine Premier League free transfers of the decade IN DEMAND targets Wan-Bissaka has been one of the Premier League’s best full-backs this season Leicester City are considering a £40m bid to sign on-loan midfielder Youri Tielemans permanently from Monaco. (Daily Mail)Manager Marco Silva wants Everton to sign on-loan Barcelona midfielder Andre Gomes on a permanent deal, with Inter Milan also interested in the Portugal international. (Liverpool Echo)Seamus Coleman wants the Toffees to spend big in the summer if they seal a return to European football. (The Independent) Tony Cascarino backs Everton to sign two strikers for Carlo Ancelotti 3 targets Getty Where every Premier League club needs to strengthen in January LIVING THE DREAM moving on Cavani ‘agrees’ to join new club and will complete free transfer next summerlast_img read more


first_imgAs flu season is among us, the Jackson County Department of Public Health (JCDPH) urges all residents to protect themselves by getting vaccinated against the flu.  During the 2014-2015 season, North Carolina recorded its highest number of flu-associated deaths in six years.  This is a reminder that flu can be a serious illness, especially for adults over the age of 65 years, children under five, pregnant women, and those with certain medical conditions such as asthma, diabetes, or heart disease.JCDPH will begin offering flu vaccines to the public on Monday, October 3rd.  Vaccines are available at the Health Department anytime Monday-Friday from 8 AM- 5 PM. Additionally, the Health Department will offer a Drop-in Flu Clinic on Saturday, October 8th from 10 AM-2 PM.  No appointments are necessary and a variety of insurances can be billed.For questions about the flu, call the Flu Line at 828-587-8201 or the Health Department’s main line at 828-586-8994last_img read more

SA legal firm in UK outsourcing deal

first_imgLegal firm Eversheds South Africa is to pilot an innovative joint venture with Eversheds UK to provide a range of outsourced legal services more cost-effectively to the firm’s UK clients. 25 January 2010 During the pilot, two associates from Eversheds’ Johannesburg office will be sent to Eversheds’ Cardiff office to acquire an understanding of their clients’ requirements. Once they move back to South Africa, after about six months, they will continue to liaise directly with the UK clients, while still reporting to their team leader in Cardiff, UK. The new services will include high-volume work such as mortgage repossessions and insurance recoveries on a case-ownership basis, while personal injury claims and employment tribunal work may be taken on at a later stage. This initial project acted as a catalyst in developing discussions to provide services for other clients, from February 2010 onwards, in a joint venture between the firm’s UK and Johannesburg offices. Low-cost centres “This is different to the outsourcing concept followed by many organisations, where work is mainly outsourced because it only requires low-level skills,” Laurenick said. “The manner in which legal services are delivered is in the process of undergoing enormous transformation worldwide and we are excited to be trendsetters for this new outsourcing concept,” said Eversheds South Africa chairman Terry Mahon.center_img “We provide high-quality professionals and the same quality of legal expertise as our UK office with good turnaround times at lower rates than the UK, simply because overheads for legal services are lower in South Africa and the exchange rate is in our favour.” “Discussions with our UK office started in December 2009 about the drafting of leases for a major UK based client, who had requested that this service be outsourced in order to cut costs,” Sven Laurencik, a partner at the Johannesburg office that is managing the joint venture in South Africa, said in a statement this week. “The key is to build trusted relationships with clients and, once these are established, we will review the success of the pilot,” Laurenick said. “In addition, the firm has an excellent infrastructure that allows us to take on high volumes of additional work at a higher level of complexity than the type of work that may be outsourced to other ‘low-cost centres’. “Eversheds operates internationally as one, and it makes sense for us to use our network of offices to move work from higher-cost centres to lower-cost centres, giving clients the benefit of a high-quality service, but delivered cost- effectively.” SAinfo reporterWould you like to use this article in your publication or on your website? See: Using SAinfo materiallast_img read more

Security and Risk Management: Four Vectors Repositioning the Direction of Today’s Security Market

first_imgSoftware, IT and technology have been in a constant state of rapid change for some time.  Specifically, in the area of security and risk management, businesses are rethinking their current strategies.Gartner recently identified what they are calling the four vectors that are repositioning the security market:By 2020, three-quarters of security products will include capabilities powered by advanced analytics, artificial intelligence, machine learning, and heuristics.Regulatory requirements will increasingly drive demand for security software.Vendors of mature security products will try to keep pace with changes in the market by acquiring and integrating new products and technologies, often from startups, into their existing products.Businesses are increasingly adopting software-as-a-service (SaaS) because of the business benefits, and as a result, will also look for SaaS security solutions.Deborah Kish, principal research analyst at Gartner, said that “the overall security market is undergoing a period of disruption due to the rapid transition to cloud-based digital business and technology models that are changing how risk and security functions deliver value in an organization. At the same time, the threat landscape and rise in the number of high-impact security incidents are also creating demand for security technologies and innovations that deliver greater effectiveness.”last_img read more

Can a multibillion-dollar biotech prove its RNA drugs are safe for a rare disease?

first_img V. Altounian/Science Earlier this year, Paolo Martini, who heads rare disease research at the closely scrutinized biotech company Moderna Therapeutics in Cambridge, Massachusetts, visited the Middle East. He met with doctors who treat children with a rare metabolic disorder known as methylmalonic acidemia—more prevalent in the region than most places because of the custom of marrying close relatives—that causes a toxic acid to build up in their blood. Soon, his team hopes to start enrolling these children in a pioneering clinical trial that delivers “messenger RNAs”—the molecules that normally carry instructions from a cell’s DNA to its proteinmaking machinery. But Moderna, which has raised billions of dollars on the promise of treating a wide range of diseases with such RNA, first has to prove that its drugs are safe for long-term use.In a study published online today in Cell Reports, the company shows that there were no obvious health problems in mice given repeated doses of its latest generation of messenger RNA (mRNA) drugs. The finding is far from definitive evidence of safety, but it’s some of the first published animal research supporting the use of this type of RNA as long-term therapy in diseases like methylmalonic acidemia (MMA). “It’s good news for the mRNA delivery field and an important step,” says Kathryn Whitehead, a chemical engineer at Carnegie Mellon University in Pittsburgh, Pennsylvania, who was not involved in the study.MRNA excites scientists because its powers are broad. If you can put new mRNA into a cell, you can theoretically tell it to make any protein. Missing an enzyme that helps break down food? Send in mRNA to resupply it. Need to heal tissue around a damaged heart? Inject mRNA coding for a growth-promoting protein. “I don’t know if I’ve ever been more excited about a class of drug than I am about [mRNA],” Whitehead says.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)But lots can go wrong when you try to sneak such molecules into the body. Our immune system has evolved to recognize RNA from outside the cell as an invading virus and attack it. The protective nanoparticles made of lipids commonly used to encapsulate mRNA can also trigger immune reactions and damage the liver at high doses. And the body might even recognize the newly produced protein as foreign—a problem if you’re trying to replace a vital protein that’s missing. Any of those responses could render an mRNA drug toxic at doses still too low to treat disease.Six-year-old Moderna has promised to engineer its way out of those traps. Researchers there have altered the chemistry of the mRNA itself so it doesn’t set off receptors on roving immune cells. The company has begun human testing of its mRNA drugs for cardiovascular disease and cancer, and for vaccines against the flu, Zika, and chikungunya viruses. And it’s not alone. Germany-based biotech companies CureVac and BioNTech are also testing several mRNA-based cancer vaccines in clinical trials.But those drugs are designed to work in just one or a few doses. To treat genetic diseases where a key protein is absent or defective, companies will need an mRNA drug that’s safe and effective for repeated use throughout a patient’s life. Some have been skeptical that’s achievable. Early generations of Moderna’s drugs didn’t meet that standard in animal tests, acknowledges its president, Stephen Hoge; over time, liver toxicity and immune reactions reared their heads.But Moderna’s newer drugs don’t have those problems, he says, thanks in part to a careful redesign of their delivery vehicle, the lipid nanoparticle. A key innovation—to be described in another forthcoming paper—is that the nanoparticle quickly sheds one of its key lipid components upon entering the body, rendering it stealthier and less toxic.In the new study, Moderna worked with scientists at the National Institutes of Health in Bethesda, Maryland, to test how effectively that new nanoparticle delivers mRNA encoding the protein that’s missing or defective in MMA patients. The enzyme, known as methylmalonyl-CoA mutase (MUT), is made primarily in the liver, and it helps break down proteins and fats in food. Without it, the buildup of methylmalonic acid in the blood can cause weakness and slowed development, kidney and liver damage, and even seizures and stroke. Children diagnosed with MMA must eat a restrictive diet, and some undergo liver transplants.In Moderna’s study, the researchers gave intravenous injections of MUT-encoding mRNA to mice lacking the enzyme. The treatment reduced blood levels of toxic acid by up to 85%, they revealed today. After getting weekly injections for 5 weeks, the mice did not have elevated levels of liver enzymes that signal toxicity, and there was no increase in certain markers of inflammation, or in antibodies that indicate an immune response.“We saw these mice not only surviving but gaining weight, turning almost into a normal mouse,” Martini says. “These data I think [are] the validation, at least in animal models, that this messenger RNA therapy could work.”Other researchers want to see much more evidence of long-term safety. “This is a good first step,” says geneticist Inder Verma of the Salk Institute for Biological Studies in San Diego, California. He would have liked to see the mice followed for longer and given even higher doses, he says. In a study published earlier this year, his team, along with scientists at Arcturus Therapeutics, treated hemophilia in mice using mRNA that encodes a clotting protein. The drug, administered in three doses over 5 months, did prompt temporary spikes in certain inflammatory molecules, which indicate a mild immune reaction to the drug. “I don’t think our paper or this paper adequately addresses the issue of long-term toxicity due to the immune system,” Verma says.To please regulators that would ultimately greenlight clinical trials, Moderna will have to show its drug is still safe at a dose 10 times higher than what’s needed to treat the disease—something the new paper doesn’t demonstrate, says geneticist Michael Heartlein, chief technical officer at the competing mRNA company Translate Bio in Cambridge. “That’s what I’d like to see, to really nail it and say, ‘Hey, they’ve really got something that’s viable for the clinic.’” (Translate is planning human trials with repeated doses of its own mRNA drug for both cystic fibrosis and a rare metabolic disorder called ornithine transcarbamylase deficiency in 2018, but it has not yet published animal studies with repeat dosing.)Hoge says he’s already confident the drug’s safety can exceed that factor-of-10 standard. These mice have been followed for several more weeks with no signs of toxicity, and Moderna has similar results from nonhuman primate studies that they plan to publish soon, he says. Martini notes that his Middle East trip has doctors there anxiously watching for a possible new drug. “Seeing the hope in the eyes of these physicians … of potentially having something to test was incredible.” Moderna Therapeutics is betting that messenger RNA can turn cells into factories for missing proteins. By Kelly ServickDec. 19, 2017 , 12:15 PM Can a multibillion-dollar biotech prove its RNA drugs are safe for a rare disease?last_img read more

Mane scores hat trick as Liverpool routs Porto, 5-0

first_img‘A complete lie:’ Drilon refutes ‘blabbermouth’ Salo’s claims Ronaldo scores 2 as PSG learns Champions League lesson Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games At the other end, Virgil van Dijk marshaled Liverpool’s defense on his Champions League debut for the club following his winter switch from Southampton.Firmino got the goal his performance deserved with a simple finish inside the left post from Milner’s cross with 20 minutes remaining, and Mane took advantage of some lax defending to seal the win with a fine strike from distance late on.“We needed to play as a team and that’s what we did,” Mane said after his first hat trick for Liverpool. “We played great football, created great chances and scored five goals. I enjoyed the fifth goal the most.”Casillas’ former side, Real Madrid, came from behind to beat visiting Paris Saint-Germain 3-1 in the other Champions League game on Wednesday.Sports Related Videospowered by AdSparcRead Next BeautyMNL open its first mall pop-up packed with freebies, discounts, and other exclusives Do we want to be champions or GROs? – Sotto Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ MOST READ PH military to look into China’s possible security threat to power grid ‘We cannot afford to fail’ as SEA Games host – Dutertecenter_img Hotel says PH coach apologized for ‘kikiam for breakfast’ claim Don’t miss out on the latest news and information. LATEST STORIES SEA Games: PH still winless in netball after loss to Thais “It was hard work, but in the end the boys enjoyed it,” Liverpool coach Juergen Klopp said after the club’s first appearance in the knockout stage of the Champions League for almost nine years.“I saw a lot of fantastic performances tonight and a result like this is only possible if everyone is really at the top of their game,” Klopp said. “They did it well and that’s the only way to be successful.”FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games openingLiverpool is the top-scoring side in the competition with 28 goals.“We knew we were facing a great team but we weren’t expecting this,” said Porto defender Alex Telles, whose team was without injured midfielders Danilo Pereira and Andre Andre. Striker Vincent Aboubakar was also out with a muscle problem. Liverpool’s Sadio Mane celebrates after scoring his side’s fifth goal during the Champions League round of sixteen first leg soccer match between FC Porto and Liverpool FC at the Dragao stadium in Porto, Portugal, Wednesday, Feb. 14, 2018. (AP Photo/Luis Vieira)PORTO, Portugal — Liverpool put one foot in the Champions League quarterfinals with a 5-0 away rout of Porto in the first leg of their last-16 match on Wednesday.Sadio Mane scored a hat trick and Mohamed Salah and Roberto Firmino provided the other two goals to give the Premier League side a huge advantage ahead of the second leg at Anfield on March 6.ADVERTISEMENT A mistake from Porto goalkeeper Jose Sa allowed Mane’s shot to squirm under his body after a slow start from the visitors, and Salah displayed all his class to make it 2-0 four minutes later inside the first half-hour.James Milner hit the post but Salah was well-placed to take the rebound, lift it with his left foot and then head it past Sa before slotting into the empty net without letting it touch the ground.It was the African player of the year’s sixth goal in the competition, and his ninth in eight games across all competitions.The home side showed promise after the break but was caught on a counterattack when Sa saved Firmino’s effort, only to push the ball toward Mane’s feet. The Senegal striker needed no second invitation for his second goal.Sa was playing in place of Iker Casillas, dropped earlier this season after falling out of favor with Porto coach Sergio Conceicao, who must have been reconsidering his decision after a shaky performance from the 24-year-old Sa.ADVERTISEMENT View commentslast_img read more